Dharamsala: The Himachal Cricket Association on Tuesday announced that the refund of the tickets of the abandoned first T20 International match between India and South Africa will begin from Thursday. The T20I between India and South Africa here on September 15 was abandoned due to heavy rain without a single ball being bowled. Since the toss was also not held, the viewing public is entitled to get a refund of their tickets. The HPCA said the refund to the customers who bought tickets off-line through the official stadium Box office at gate 1 will be done from September 19 to 22. Also Read – Puducherry on top after 8-wkt win over ChandigarhThe customers will have to produce their physical tickets along with their government-issued photo ID proof to claim the refunds at the stadium Box Office from 10 am to 7pm. The HPCA said that if the tickets were purchased though card payment at the sale box, one must carry that physical card with which the payment was made to get the refund. A maximum number of four tickets per person shall be refunded as was the rule during purchase too. The refund of tickets of West Stand (West 1, 2 & 3), Pavilion Terrace and Corporate Boxes will also be done on Thursday. Tickets of East Stand (East 1, 2 & 3) and Club Lounge Pavilion will be refunded on Friday. The refund of tickets of North Stand, North Pavilion and North West will be done on Saturday and Sunday. Customers who have bought tickets online from paytm.com and/or insider will get back their money within 10 12 working days from Tuesday onwards and refunds will be credited to their original mode of payment. The refund of the tickets will be made for the face value of the ticket only.
TORONTO — Canadians who are worried they might be victims of the Equifax Inc. hack say they are being treated as an afterthought in the wake of one of the largest online data breaches in history.The company has provided consumers in the U.S. with a website that shows whether they are at risk of identity theft and is allowing them to monitor their files for free for one year.But the online database does not provide Canadians with accurate information because it is based on U.S. social security numbers. The Equifax Canada website says it costs $19.95 per month for the same monitoring service.Toronto lawyer Frances Macklin said she is frustrated that Canadians are being treated worse than their U.S. counterparts and questioned why there isn’t a dedicated portal for consumers north of the border.“We’re equally affected. Just because I don’t have a social security number, I don’t get access to information,” said the partner at Gowlings law firm. “I’m completely bewildered by that.”Equifax Inc. said last Thursday that a security breach occurred over the summer that compromised the private information of up to 143 million Americans, along with an undisclosed number of Canadians.But the company has not provided further details, including how many Canadians may have been exposed. Equifax Canada did not immediately respond to requests for comment.However, Equifax Canada’s customer service agents have told callers that only Canadians who have had dealings in the United States are likely to have had their information compromised in the data breach.The credit monitoring company’s call centre staff said that Canadians who have Equifax accounts in the U.S. could be at risk of having their data compromised, such as those who have lived, worked or applied for credit south of the border.Equifax Canada’s website says that “only a limited number of Canadians may have been affected” and it is working to find out how many.It adds that personal information that may have been breached includes names, address and Social Insurance Number and “the breach is contained.”Robert Johnson, lead plaintiff in a proposed class action lawsuit against Equifax Canada filed in Saskatchewan, said he is upset that Canadians have only been told that a limited number have been compromised.The Regina business analyst said he trusted them with his personal information and does not understand why it is taking so long to provide more information about the hack, which was discovered on July 29.Communications expert Warren Weeks believes Equifax could not have handled this issue in a worse way.“We’re talking about the gateway to all of your financial information in your life,” said Weeks, who is the principal of communication firm Weeks Media Group.“And Canadians, in specific, don’t know if they’ve been targeted or not or they’ve been impacted or not? I think in 2017, that’s unacceptable.”
DURHAM, N.C. — RJ Barrett didn’t know how close he was to a triple-double. The Duke freshman was having too much fun to check the box score.Barrett had 26 points, seven rebounds and a season-high seven assists, and the third-ranked Blue Devils routed Stetson 113-49 on Saturday night.“I was just having too much fun out there” to worry about the stats, Barrett said.Cameron Reddish scored 23 points and Zion Williamson finished with 17 to help the Blue Devils (7-1) win their second straight.Duke shot a season-best 58 per cent, and had season highs of 19 steals and 27 turnovers forced while reaching triple digits for the first time since the season-opening 118-84 rout of then-No. 2 Kentucky.“That’s what happens when we play hard and play together,” Barrett said. “We play defence and turn it into offence.”Barrett played just 17 minutes, but that was long enough to challenge for Duke’s first triple-double in nearly 13 years.According to the school, he’s the first player in program history with that many points, rebounds and assists plus four steals in a game. He was taken out for good with 15:38 left and the Blue Devils up by 50.“I thought we’d play the starters more in the second half, and then we just exploded,” coach Mike Krzyzewski said.Abayomi Iyiola scored 19 points to lead the Hatters (1-8), who have lost eight straight and were 2 of 23 from 3-point range.BIG PICTUREStetson: The rebuilding Hatters have yet to beat a Division I team this season, haven’t beaten a Top 25 team since 1982 and lost five key players from last year. So expecting them to be competitive might have been asking too much from the No. 338 team in Ken Pomeroy’s efficiency rankings. At least they led — on three separate occasions early, by one point each time, for a total of 34 seconds.“I’ve never faced a team like that since I’ve been at Stetson,” sixth-year coach Corey Williams said. “They are certainly more than advertised, and we had to play a flawless game to even keep it close.”Duke: This was the epitome of a taking-care-of-business victory for the Blue Devils, 43-point favourites who didn’t receive even a whiff of a test after the first few minutes. The only drama in the second half was whether Barrett — who made 12 of 14 shots — would check back into the game and try to become the fourth Duke player with a triple-double and the first since Shelden Williams in January 2006.BARRETT-OMETEROne brilliant 30-second stretch encapsulated the night for Barrett — who had six points and two steals in that span. First, he banked in a jumper. Then he stole a pass and went in for a dunk, but he wasn’t done: He then stole the ensuing inbounds pass and dunked to make it 43-16 and force Stetson into a timeout.JONES WATCHDon’t worry too much about freshman point guard Tre Jones going scoreless for the first time at Duke. While he missed his only shot, he played just 15 minutes and did have seven assists.SYMMETRYA bit of trivia from this result: Both the first and (for a few days, anyway) the most recent victories for Krzyzewski at Duke came almost exactly 38 years apart against Stetson. Coach K’s first Duke team beat the Hatters 67-49 on Nov. 29, 1980.RECORD WATCHDuke earned a line in the record book — the 64-point margin of victory was tied for the seventh-largest in program history, and this was the Blue Devils’ most lopsided win since last year’s 64-point rout of Evansville.UP NEXTStetson: Hosts Western Illinois on Wednesday night.Duke: Plays host to Hartford on Wednesday night.___More AP college basketball: https://apnews.com/Collegebasketball and https://twitter.com/AP_Top25Joedy McCreary, The Associated Press
This means that individual defensive efforts are becoming less and less involved in the outcome of games. For example, the combined assists and putouts of shortstops have declined by 13 percent since 2007, from 21,495 in 2007 to a projected mark of around 19,000 this season. Second basemen saw 23,704 combined chances in 2007 compared with 21,057 last season. Center fielders caught 12,829 fly balls in 2007. They grabbed 11,437 last season.If there are fewer defensive chances available, teams can make the argument that it’s more valuable to chase runs, particularly in an era of launch angle, juiced balls and smaller stadiums.This season, 68 players have made “primary” position changes, playing the majority of their innings at a different position than they played last season. Thirty of those players graduated to more difficult defensive positions — both of those marks are five-year highs. Players who moved up the defensive spectrum include Manny Machado, who moved from third base to shortstop in Baltimore earlier this season and stayed at short when he was traded to Los Angeles last month. The Cubs at times dispatched Kris Bryant to center field in 2015, ’16 and ’17. The Reds experimented with moving their top prospect, Nick Senzel, from third to shortstop this spring. The Indians, whose pitchers set a record for strikeouts last season, played second baseman Jason Kipnis in center field at the end of the regular season and in the American League Division Series against the Yankees — Kipnis hadn’t played center regularly since he played at Arizona State.The Indians have also sent Lonnie Chisenhall and Brandon Guyer to center field over the past two years. “There are always trade-offs between offense and defense,” Bloom said. “When there are trade-offs, you try to take note of all those factors, including the environment, and make the best assessment you can.”The decline of balls being put in play is not the only leaguewide trend testing the traditional value and labels of defense. This era of specialization has required the erosion of primary positions.Individual pitchers are absorbing fewer innings. Roles are changing. They Rays introduced “the opener” earlier this season, a new label attached to a relief pitcher who starts a game but only appears for an inning or two. For several seasons, the Rays have rarely let their starting pitchers work through an opposing lineup three or more times. Only 15 pitchers reached 200 innings last season, which tied 2016 for the all-time low mark. More roster spots are being occupied by bullpen arms to absorb innings and seek favorable in-game matchups. Position-player roster spots are further stretched by the popularity of platoons.“You see teams using more platoons, defensive replacements late in games,” Kipnis said this spring. “You put in the offensive guy early, you get the lead … and he comes out for a better defensive player. It’s kind of the reverse of having a pinch-hitter come in late, basically.”The Cubs’ Ben Zobrist is the 21st-century poster child of defensive versatility. He wasn’t just a glove-first utility player asked to fill in around the diamond earlier in his career in Tampa Bay; he was a star-level bat who could play about anywhere on the field.“I think one of the things that made Ben so successful here was his willingness and selflessness to go do it and be an upper-echelon player,” Bloom said. “It set an example for a lot of guys in the league.”This season has seen a record number of Zobrists. Six players have appeared in at least one game this season at every position other than pitcher and catcher: Marwin Gonzalez, Enrique Hernandez, Yadiel Rivera, Sean Rodriguez, Andrew Romine and Hernan Perez.Last year, 25 players played at least 10 games in left, right and center field, an MLB record. The number of players to play at least 10 games at second, third and shortstop in a given season is on the rise, too, with a record 20 players doing so in 2016. The top 12 such seasons have all occurred since 2000. A record 27 players played at least 10 games at third and shortstop in 2016, and the 24 players to do so in 2017 tied for second all-time.Oakland infielder Jed Lowrie has played every infield position in his career and both second and third this season. “You are still going to want your elite defenders in the middle of the field,” he told FiveThirtyEight. “That’s where the majority of the action happens. But versatility allows a team to match up in more favorable ways.”Also warping the traditional idea of positions and labels is alignment.Defensive shifts have become a common part of the game and changed the meaning of what it is to play second base or shortstop. This trend began when the Brewers and Rays ushered regular infield shifts into the game in the early 2010s. When shortstops are routinely playing on the right side of second base and second basemen are sometimes playing shallow right field, they cease to become traditional shortstops and second basemen. And alignment has only become more extreme, creative and aggressive. In April, Seattle second baseman Robinson Cano began a pitch 221 feet away from home plate against Texas slugger Joey Gallo, which was the farthest back an infielder had aligned in the Statcast era, according to Daren Willman of Baseball Savant.2The average second baseman stands 151 feet from home plate.In 2015, MLB teams played four-man outfields on 17 occasions, according to Statcast data. There were nine instances of four-man outfields in 2016 and seven last season. This year? The number has jumped to 194. The Rockies, Cubs, Twins, Dodgers, Orioles, Mariners and Astros have all experimented with this tactic.There are limits to versatility and stretching labels. Russell Carleton found for Baseball Prospects earlier this month that the defensive spectrum might need rethinking, arguing that positions are skill-specific and that the penalty of moving some players to more challenging positions is greater. “Each position is its own box and the boxes are a lot less similar to each other than we might have thought,” Carleton wrote. Carleton found that over a 162-game season, sliding an “emergency” shortstop up the spectrum cost a club about 26 runs — more severe than the generally accepted penalty of 20 runs surrendered between position leaps on the spectrum.Certain positions require certain skills and physical traits. Second baseman and shortstops require quick and capable hands to turn double-plays and react to line drives and grounders hit in excess of 110 mph off the bat. To competently man the position, shortstops should be able to make a throw to first from the deep hole between shortstop and third. Still, given the right strikeout and ballpark environment, and with enough offensive production, moving certain players up the spectrum can add value.“I don’t think we’ll get to the point where those elite skill sets and athleticism won’t be prized,” Bloom said. “It think that’s always going to be something teams look for.”But where those players play, and what we label them, will likely continue to evolve. The game is changing more quickly than ever, and so are positions as teams attempt to adapt. Just as the Brewers brought defensive shifts to the NL earlier in the decade, they now have the game thinking about the nature of positions, labels and trade-offs once again.Check out our latest MLB predictions. On Aug. 3, shortly after being acquired by Milwaukee in a deadline deal from Baltimore, Jonathan Schoop found himself in an unusual position on the Miller Park infield. For just the third time in his six-year career, he was starting at shortstop. He wasn’t alone that day. His middle-infield teammate, Travis Shaw, was starting just his fourth game at second base — a position he had never played as a professional before this season.The Brewers had a surplus of corner bats entering the year, and they added even more at the trade deadline, bringing aboard third baseman Mike Moustakas from Kansas City. At this point, they have more starting-caliber infielders than positions available. This is all part of a grand Brewers experiment as they chase a playoff spot: Trade defense for offense and cram as much power into their infield as possible.In other major sports, positional labels have become less and less important, so why not baseball? In the NBA, centers and power forwards now routinely shoot threes, in part to increase their offensive efficiency. Defensive versatility, the ability to switch, is more and more valued. In the NFL, teams like the Patriots have valued positional versatility. And position labels are increasingly becoming irrelevant in professional baseball.“I do think you are seeing a greater willingness by teams to expand the definition of what’s possible and not be as bound by the way things have always been,” Chaim Bloom, the vice president of player development for the Tampa Bay Rays, told FiveThirtyEight.This is more feasible now in part because of the current baseball landscape. Strikeouts continue to climb: 22.1 percent of plate appearances this season have ended in a K, which would set a new record. Strikeouts are up half a percentage point over last season — equivalent to more than 800 balls taken out of play. Moreover, a record number of home runs were hit last season, and while while home run rates are down, 5,000-plus balls will be hit out of ballparks by the end of this year.Strikeouts and home runs are putting a considerable damper on the number of batted balls put in play, which were down 14.5 percent last season compared with 1980.1Adjusted for the number of teams in the majors. Since 1998, when the game expanded to 30 teams, there’s been an 8.8 percent decline, and the decline was 7.8 percent since 2008. The trend is expected to continue again this season.
Tweet thisShare on FacebookEmail this article Wednesday 28 Feb 2018, 7:00 PM Image: Sam Boal/RollingNews.ie Here’s what to do if you see a homeless person sleeping rough tonight In Dublin last night there were over 200 reports about homeless people sleeping rough. Image: Sam Boal/RollingNews.ie 61,201 Views Share635 Tweet Email2 https://jrnl.ie/3876898 HOMELESS SERVICE HAVE thanked members of the public who got in touch overnight out of concern for people they had seen sleeping rough in the severely cold weather.Dublin City Council’s homeless executive had 220 reports through its rough sleeper alert system, which it is asking members of the public to use if they have a concern about a homeless person. Short URL Feb 28th 2018, 7:01 PM You can find the reporting system here.“This has enabled the Housing First outreach teams to locate and engage with people sleeping rough and work with them to access shelter and more importantly the teams have been able to engage with people who would not normally come into services,” the homeless executive said this morning.The Inner City Helping Homeless voluntary organisation will have outreach teams working again tonight and they can be alerted to anyone sleeping rough by calling 01 8881804 or 085 8389281.Here’s what to do if you are in other parts of the country and have concern for a homeless person:In Kildare, the Peter McVerry trust is operating the freephone line, which is 1800 804 307.Meath County Council advises members of the public use its out of hours number, 1890 445 335.Louth County Council can be contacted out of hours on 1890 202 303.For services in Kilkenny, you can call Good Shepherd Centre on 056 7722566 or the council’s emergency call centre number 056 7794145.In Cork, you can contact the homeless persons unit on 021 4963 052.Cork Simon has an Emergency Shelter on Anderson’s Quay. Their number is 021 4278 728.The number for the Society of St Vincent de Paul in Cork is 021 4317 899 and Pathways, which is for male teens aged 14 – 17 yr old can be contacted on 021 4507 050. The Limerick Homeless Action Team can be reached on its freephone out of hours number: 1800 606060.In Galway you can call Cope homeless services on 1800 788887.To alert services in Kerry, you can call Arlington Lodge shelter in Tralee on 066 719 3800.All of the local authorities have expanded their emergency accommodation provisions for the duration of the storm. Each of the local authorities have a general out of hours emergency number which can also be used and as a last resort, you can contact your local garda station.‘Distressing rise in homeless figures’Taoiseach Leo Varadkar earlier today acknowledged that the latest figures, which showed an increase in the number of people presenting as homeless, “are bad” and “distressing”.In total, there were 1,517 families with 3,267 children staying in emergency accommodation in January.This marks a rise of 109 families and 188 children since December.There were 5,837 homeless adults in emergency accommodation in January, a rise of 158 on the previous month.He said the rise in the figures is “disappointing” and shows government will have to redouble its efforts. “It is going to take time to get on top of this problem,” Varadkar said.At the moment, he said his main concern is people who may be sleeping rough during the severe weather over the next number of days.Read: Dublin homeless executive received over 200 reports about rough sleepers overnight> By Michelle Hennessy 24 Comments
Énergie renouvelable : un Savoyard réalise un France-Japon en vélo solaireFrance – Florian Bailly, jeune Savoyard de 27 ans, est arrivé à Tokyo après avoir parcouru quelque 10.000 kilomètres sur un vélo électrique fonctionnant à l’énergie solaire. Parti de Savoie en juin dernier, il aura mis quatre mois pour réaliser cet exploit sportif et technologique.C’est sur un prototype de bicyclette développé avec l’Institut national de l’énergie solaire (Ines) que Florian Bailly a effectué son périple écologique. Ce vélo est équipé de panneaux transmettant l’énergie à deux batteries lithium-fer-phosphate fixées à l’avant et à l’arrière du deux-roues. Cette électricité alimente un petit moteur fixé sur le pédalier, permettant au jeune homme de parcourir en moyenne 115 kilomètres par jour. A la seule force des jambes, il n’aurait pu parcourir quotidiennement que 80 à 90 kilomètres.À lire aussiLa Chine vient de construire une ferme solaire en forme de… panda géantFlorian Bailly a roulé environ cinq heures par jour. Il a traversé les plaines italiennes du Pô, les contrées de Slovénie, la Croatie, la Serbie, la Roumanie, l’Ukraine et la Russie, avançant à 30 km/h environ sur route plane grâce au soutien électrique de son vélo solaire. A chaque pause, le jeune homme a déplié ses panneaux solaires pour accélérer le stockage d’énergie. Après des journées peu ensoleillées, il branchait ses batteries sur secteur pendant la nuit.Après avoir cassé son pédalier sur les routes non asphaltées du Kazakhstan, Florian Bailly a réussi à le réparer et a rejoint le Kirghizstan. Arrivé en Chine, il a traversé le désert du Taklamakan, parcourant 4.000 kilomètres dans l’Empire du milieu avant d’atteindre Shanghaï, où il a été reçu à l’Exposition universelle.Le jeune homme a enfin embarqué sur un bateau en direction d’Osaka, au centre-ouest du Japon, rejoignant Tokyo le 7 octobre. “J’ai mis quatre mois pour tout boucler, il m’en aurait fallu six sur un vélo normal”, estime l’aventurier. “Dans quelques années, on devrait pouvoir fabriquer des panneaux solaires de voyage et des batteries plus légères. Cela permettrait à beaucoup de voyager écologique” s’enthousiasme celui qui envisage désormais d’organiser “un rallye à vélo solaire électrique France-Japon, sur le modèle des courses de bateau”.Le 15 octobre 2010 à 13:18 • Emmanuel Perrin
L’OMS et l’Unicef partent en croisade contre la polioL’Organisation mondiale de la santé (OMS) et l’Unicef ont lancé hier un “plan d’urgence” contre la poliomyélite. En effet, ces dernières années, une recrudescence de cas a été observée en Chine et en Afrique où la maladie avait pourtant disparu.La poliomyélite est une maladie qui touche les enfants de moins de cinq ans et entraine une fois sur 200 une paralysie irréversible. Parmi les enfants paralysés, 5 à 10% meurent lorsque leurs muscles respiratoires cessent de fonctionner. Face à une recrudescence de cas en Chine et en Afrique de l’Ouest où la maladie avait pourtant disparu, l’Organisation mondiale de la santé (OMS) et l’Unicef, en partenariat avec d’autres partenaires humanitaires, ont lancé un “plan d’urgence”. À lire aussiPourquoi certains s’évanouissent-ils à la vue du sang ?Toutefois, l’organisation estime qu’il manque 945 millions de dollars (soit la moitié des fonds nécessaires) pour parvenir à éradiquer la polio dans le monde. “L’éradication de la polio est sur le point soit de réussir, soit d’échouer”, a averti la directrice générale de l’OMS, Margaret Chan. Elle a donc appelé les Etats à “agir mieux et plus vite, en se concentrant sur les zones où les enfants sont les plus vulnérables”. Malgré les progrès considérables de certains pays, la maladie reste endémique en Afghanistan, au Pakistan et au Nigeria.Pour l’OMS et ses partenaires (la Fondation Bill & Melinda Gates ainsi que le Rotary International, entre autres), il pourrait y avoir d’ici dix ans 200.000 enfants paralysés par an dans le monde si la polio n’est pas éradiquée totalement. De plus, outre les enjeux humains, l’éradication totale de la polio engendrerait des bénéfices nets de 40 à 50 millions de dollars (32 à 40 millions d’euros) dans le monde, surtout dans les pays à faible revenu, d’ici 2035.Le 25 mai 2012 à 16:31 • Maxime Lambert
Stay on target Machine Learning Estimates Risk of Cardiovascular DeathMIT’s Color-Changing Ink Lets You Customize Shoes, Phone Cases Static accessories are so 2016: Researchers at the Massachusetts Institute of Technology have created “living” jewelry.The miniaturized robots, dubbed Kino, meander across your clothes, changing location and reconfiguring appearance.Its various applications, as described by its inventors, include pattern-changing effects (camouflage the bots then watch them create optical illusions on your torso) and etching (the device can “draw” on fabrics like velvet).Miniature robots generate dynamic textile patterns through movement (via Jimmy Day/MIT)With Kino, high tech meets high fashion: The kinetic wearables seamlessly transition between a minimalist brooch for the office and a statement necklace for the theater.The rise of smart jewelry—”adornment artifacts that function both as jewelry and as a computational device,” as the researchers put it—has so far been limited to alphanumeric displays or LEDs.But add some wheels and sensors, and you can open design to functions beyond decoration.Kino robot mechanical structure (via Jimmy Day/MIT)“It is our vision that in the future, these robots will be miniaturized to the extent that they can be seamlessly integrated into existing practices of body ornamentation,” the team said in a product overview.Kino can even trigger clothing to adapt based on climate or comfort needs. For instance, connect a device to each drawstring of a jacket hood, and, upon detecting an increase in temperature, the robots automatically roll down to pull off the cowl.They can also be paired with mobile devices to act as on-body assistants, responding to commands and completing tasks.Climate-reactive clothing application (via Jimmy Day/MIT)“With the addition of kinetic capabilities, traditionally static jewelry and accessories will start displaying life-like qualities, learning, shifting, and reconfiguring to the needs and preferences of the wearer, also assisting in fluid presentation of self,” according to the scientists.The group, led by MIT Media Lab’s Chris Schmandt, includes Media Lab analysts Cindy Hsin-Liu Kao and Artem Dementyev, MIT mechanical engineer Deborah Ajilo, fashion designer Oksana Anilionyte (of London’s Royal College of Art), and Stanford University mechanical engineers Inrak Choi and Sean Follmer.“With wearables that possess hybrid qualities of the living and the crafted, we explore a new on-body ecology for human-wearable symbiosis,” they added. “Attached to garments, [Kino] generate shape-changing clothing and kinetic pattern designs—creating a new, dynamic fashion.”Let us know what you like about Geek by taking our survey.
Study: Indoor Air Quality Levels ‘On Par With’ Polluted Major CitySwiss Plant Sucks CO2 Out out of Air to Repackage, Sell Stay on target There is a growing trend (pun intended) in houseplants, which offer a splash of color while helping with indoor air purification.Researchers at the University of Washington have taken urban jungles to the next level, though, by developing a common houseplant to remove toxic compounds from the air.Too small to be trapped by traditional filters, chloroform and benzene can build up in our homes when we shower, boil water, or store cars or lawn mowers in attached garages.“People haven’t really been talking about these hazardous organic compounds in homes, and I think that’s because we couldn’t do anything about them,” according to senior study author Stuart Strand, a research professor in the UW civil and environmental engineering department. “Now we’ve engineered houseplants to remove these pollutants for us.”His genetically modified Epipremnum aureum (also known as pothos ivy or devil’s ivy) essentially “eats” these toxins to support its own growth.Long Zhang puts a pothos ivy plant into a glass tube to test its ability to break down benzene or chloroform (via Mark Stone/University of Washington)Inspired by the human body, Strand & Co. opted to use the protein cytochrome P450 2E1, which, located in our livers, is turned on when we drink alcohol; it turns benzene into phenol and chloroform into carbon dioxide and chloride ions.“We decided we should have this reaction occur outside of the body in a plant, an example of the ‘green liver’ concept,” Strand said. “And 2E1 can be beneficial for the plant, too.“Plants use carbon dioxide and chloride ions to make their food,” he explained. “And they use phenol to help make components of their cell walls.”The team introduced a synthetic gene into photos ivy, allowing each cell to express the 2E1 protein. They then tested how well the doctored plants remove pollutants from air, compared to their unaltered counterparts.Spoiler alert: The experiment was a great success.After just three days, the concentration of chloroform in modified plants dropped 82 percent, and was almost undetectable by day six. Benzene also decreased, albeit more slowly, falling 75 percent in eight days.There was no change in concentration levels among the untouched pothos ivy.For plants in the home to be able to effectively remove hazardous molecules from the air, they would also need to be inside an enclosure with something to move air past their leaves, like a fan (via Mark Stone/University of Washington)These numbers should be taken with a grain of salt, considering the researchers used higher pollutant concentrations than are typically found in homes. Experts, however, believe that IRL levels would drop similarly, if not faster, over the same time frame.A fan—or something to help move air past the leaves—could also help.“If you had a plant growing in the corner of a room, it will have some effect on that room,” Strand said. “But without air flow, it will take a long time for a molecule on the other end of the house to reach the plant.”Moving forward, researchers are working to increase pothos ivy’s capabilities by adding a protein that breaks down another hazardous molecule: formaldehyde.Their findings were published last week in the journal Environmental Science & Technology.More on Geek.com:This Plant Hormone Could Help Grow Potatoes in SpaceTrying to Get Pregnant? Stop Smoking PotThis ‘Cube’ Lets You Experience the Earth’s Most Extreme Conditions
Sime Vrsaljko made it to the World Cup final against France and he has been nearing a move away from his current club, Atletico Madrid – Luciano Spalletti admitted that Inter Milan want to get him.The Croatia international was one of the brightest spots of the World Cup in Russia and it is understandable that he has become the transfer target of many clubs – and the Italian giants are working on signing him.Spalletti spoke about this possible move as he said that the situation remains unclear for him, according to Goal:Maurizio Sarri satisfied despite Juventus’ draw at Fiorentina Andrew Smyth – September 14, 2019 Maurizio Sarri was satisfied with Juventus’ performance on Saturday afternoon after finishing a tough game at Fiorentina 0-0.“We like Vrsaljko. The directors are working, certain things will be defined once our preparations begin when our squad is more settled.”“As more days pass and we approach the deadline, the situations change.”“We’re working on the pitch, so [Piero] Ausilio [sporting director] and [Giovanni] Gardini [chief administrator] are thinking about it. You also know the positions we need covering.”
Carlo Ancelotti has tipped former side Paris Saint-Germain for Champions League glory but Napoli can end those ambitions early.The first tie ended in a thrilling 2-2 draw at Parc des Princes, where PSG fought back twice to scrape a point.“It’s an important game and can be decisive for both teams,” Ancelotti told Telefoot via Football Italia.“We ended up in a very difficult group with Paris Saint-Germain and Liverpool. The result can be decisive for the future of our side in the competition, but the same goes for Paris.“We need an extraordinary performance in order to get the victory because we don’t have the kind of exceptional players they do throughout the squad.”Opinion: Neymar will earn respect back from the PSG fans Tomás Pavel Ibarra Meda – September 14, 2019 After completing his incredible return to Parc des Princes, we predict that Neymar will earn the respect back from PSG supporters.The situation between Neymar…Ancelotti effectively started Paris Saint-Germain’s domination of French football, but they have never been able to match it with Champions League results.“They’ve lacked experience in the important moments of the Champions League, but the team is stronger this season and the players have more belief in themselves. They know that they can win the Champions League this term.“This is a game that can decide the destinies of these two teams,” continued Ancelotti.“I think Kylian Mbappé and Neymar can succeed Cristiano Ronaldo and Lionel Messi on the global football landscape. If Kylian doesn’t win the Ballon d’Or this year, he certainly will over the next few seasons.“Neymar has a new position and is at the heart of the team now. His new placement allows him to be more dangerous and effective for his team.”
JOHANNESBURG – More than 10,000 people in West Africa are believed to have contracted Ebola in the biggest outbreak of the deadly disease, and nearly 5,000 have died, according to the latest World Health Organization report, amid concerns about a potential spread of the disease in Mali.Fears rose about how many people may have been infected by a 2-year-old girl before she died Friday in Mali.The child was taken by her grandmother from Guinea to the western Mali town of Kayes by bus, a journey of almost 700 miles. The child was symptomatic — and therefore infectious — for much of the journey, according to the WHO. For part of the trip she was bleeding from the nose.Malian authorities have traced 43 people who were in contact with the child, including 10 health-care workers. But the long journey by public transport raises the possibility that some people who may have been infected will be difficult to trace.The WHO sent experts and equipment to Mali in a bid to ensure the outbreak doesn’t get out of hand. Though Malian President Ibrahim Boubacar Keita said Saturday that all the girl’s contacts had been found and were being monitored, the WHO said they were tracing further contacts.According to Keita, the dead girl’s grandmother went to a funeral in Guinea. Burials of Ebola victims carried out without proper safeguards are one of the main means of the transmission of the virus in West Africa.
The Scene is set to go live in July and will feature curated content from Condé Nast’s existing channels as well as content from newly announced partners including ABC News, Buzzfeed, Major League Soccer, Variety, and Weather Channel Films. “The Scene will be a place where new digital series will get first billing and won’t get buried beneath an avalanche of primetime television and user uploaded content,” says Fred Santarpia, chief digital officer, Condé Nast Entertainment, in a statement. The company says programming is currently available on 25 platforms, including AOL, Yahoo, YouTube and Roku. More platforms will be announced this year. If this week’s Digital Content Newfronts, and a recent spate of research, haven’t driven this point home already, video is the “next big thing.” Glam used the newfronts to announce a corporate branding change to Mode Media, and a strategic pivot to video. The New York Times is also putting a renewed focus on video, formally launching TimesVideo. AOL and Microsoft just partnered to expand AOL’s video content distribution. And most recently, Condé Nast joined the party with more video channels and a new curated video vertical, called The Scene, produced out of its Condé Nast Entertainment division. With the GQ and Glamour channels the first to launch this time last year, and the subsequent addition of nine more magazine-branded channels, CNÉ claims close to a billion video views. Next up are new channels for Bon Appétit, The New Yorker and Lucky—and more than 100 digital series produced across them all.
ADC AUTHOR I would like to share a quick note with ADC’s membership as the Managing Editor of the association’s On Base newsletter. As a recent member of the team, it has been a busy period learning about ADC and the interests and activities of the communities that make it a great organization.My background includes diverse work in communications and media, and includes performing writing, communications, editorial, and other media services for a range of corporate, technology and start-up firms.Most notably in regard to On Base, I have served as a Navy Journalist assigned to two U.S. aircraft carriers – the USS Midway (now a museum in San Diego), and the USS Nimitz our of Bremerton, Wash. In these roles I wrote, edited and published a command newspaper; produced on board news broadcasts; and wrote, edited and published public affairs collateral, including press kits, press releases and informational materials.As On Base evolves, we would like to share that ADC is interested in hearing quality of life stories and other activities happening in your communities that make them great places for our military to work and live. Send items for possible coverage to: firstname.lastname@example.orgIn the meantime, we look forward to seeing you at this week’s Defense Communities National Summit.Greg TraweekADC photo by Will Noonan
The Coast Guard has called off its search for a fisherman who fell overboard from his vessel in the Bering Sea on Wednesday.The Coast Guard isn’t releasing the man’s name, but friends, family and local news reports say he is Eric Eder. Eder was fishing aboard the F/V Seeker. The Coast Guard says it’s an 87-foot trawler based in Newport, Oregon.Eder fell from the Seeker Wednesday morning, 10 miles northwest of Unimak Island. Another vessel in the area, the F/V Seafreeze Alaska, alerted the Coast Guard. Several nearby boats were already looking for Eder by the time a Jayhawk helicopter crew got to the scene.The F/V Seeker pictured in 2006. Photo courtesy from marinetraffic.com.The Jayhawk searched for a few hours, only pausing to refuel in Cold Bay. Around 4:30 p.m., they turned the scene over to the Coast Guard Cutter Alex Haley, which came from a patrol near Unalaska.The Alex Haley searched until about 10 p.m. Wednesday. That’s when petty officer Grant DeVuyst says the Coast Guard suspended its search.“That’s always a difficult decision to make for a search and rescue team,” DeVuyst said. “Our thoughts and prayers are with the family and friends of the missing.”DeVuyst says the Jayhawk, the cutter and the good Samaritan vessels had searched for about 10 hours total. He says they’re ready to keep looking if they get any new information about Eder’s whereabouts.DeVuyst says they’ve been in touch with the mariner’s family to let them know the Coast Guard’s active search is over for now. DeVuyst says in cases like this, the mariner is legally considered missing by the Coast Guard.It’s not clear yet how Eder fell from the Seeker. Coast Guard Sector Anchorage will conduct an investigation.There was a gale warning in effect for the Unimak Island area on Wednesday, with about 10-foot seas, winds up to 40 miles per hour, snow and freezing spray.
Hartsfield-Jackson AtlantaLIU JIN/AFP/Getty ImagesAirports are getting busier than ever, and had 6.6 percent more passengers in 2017 than in the previous year. For the 20th consecutive year, Hartsfield-Jackson Atlanta International Airport has hosted more passengers than any other airport on the planet.According to preliminary 2017 travel data released on Monday by the Airports Council International (ACI), close to 104 million passengers passed through the Hartsfield-Jackson Atlanta International Airport in 2017, making it the world’s busiest passenger airport.Beijing (PEK), with 94.4 million passengers (a 1.5 percent increase) holds the second spot and Dubai (DXB) remained in the third position.Dubai International Airport is also the world’s busiest in terms of international passengers. Total passenger traffic at DXB grew 5.5 percent in 2017.The Indira Gandhi International (IGI) Airport, operated by the Delhi International Airport Ltd, is also among the top 20. Delhi Airport jumped from 22nd to 16th, solidifying its status as one of the fastest growing airports in the world for passenger traffic. Total passenger traffic in IGI airport grew by 14.1 percent in 2017.”Growing rapidly in relatively short period of time, India is poised to be one of the largest aviation markets in the world in the years to come. With an astounding population base of over 1.3 billion inhabitants, the move towards a more liberalized aviation market coupled with stronger economic fundamentals has helped to awaken the Bengal tiger to become one of the fastest growing markets in the world.ACI’s World Airport Traffic Forecasts predicts that the country will represent the third largest aviation market, in terms of passenger throughput, after the US and China by 2020″ ACI said in a report.”Even with this rapid growth in throughput, DEL was also ranked first in Airport Service Quality for airports above 40 million passengers per annum. The award, which is also shared with Mumbai (BOM), the second busiest Indian airport, is based on a derived score from a battery of passenger satisfaction metrics”, ACI noted.”Calcutta (CCU), Hyderabad (HYD), Bangalore (BLR), Madras (MAA) also ranked among the fastest growing airports in the world. Year-over-year growth of 26.9 percent, 19.6 percent, 12.9 percent and 10.5 percent respectively was achieved in 2017″, the ACI report added.Of the top 20 busiest airports, five airports – Los Angeles, Chicago O’Hare, Dallas/Fort Worth and Denver International – are located in the US.ACI report is prepared based on data from more than 1,200 airports worldwide.
Map of Kabul locating a suicide bombing attack near the heavily-fortified US embassy Tuesday. AFPA suicide bomber blew himself up on a busy shopping street near the US embassy in central Kabul Tuesday, killing four people and injuring several others, officials said.It was the latest in a series of deadly attacks to hit the Afghan capital, and comes three months after a massive truck bomb ripped through the same area, killing about 150 people.Najib Danish, a spokesman for Afghanistan’s interior ministry, told AFP the explosion happened outside a private bank.The blast happened Tuesday morning at a time when many officials were expected to be collecting their salaries ahead of this week’s Eid holiday.Kabul Bank, the private institution hit by the blast, usually pays the salaries of security forces personnel and government employees.Images broadcast on Afghan television showed the bank’s mangled exterior.Waheed Majroh, a health ministry spokesman, said one dead body and eight wounded people had been brought to Kabul hospitals so far.The blast occurred on a street lined with shops and banks leading to Massoud Square, near the United States embassy and Kabul’s diplomatic area.There was no immediate claim of responsibility but Taliban insurgents are currently at the peak of their summer fighting season, and have launched several deadly assaults around the country in recent weeks.Since NATO forces ended their more than a decade-long combat mission in Afghanistan at the end of 2014, Afghan troops and police have struggled to beat back the resurgent Taliban, while facing the growing menace of the Islamic State group.Deadly assaultsIt was the latest explosion to rock the war-weary Afghan capital, and comes a week after United States President Donald Trump committed American soldiers to Afghanistan indefinitely.On May 3, a powerful blast targeting a foreign forces convoy near the US embassy and NATO headquarters killed at least eight people and wounded 28 during morning rush hour.Later in the month a massive truck bomb tore through Kabul’s diplomatic quarter, home to the presidential palace and a host of foreign embassies, killing about 150 and wounding around 400 people, mostly civilians.And on June 3 seven people were killed after suicide bombers attacked the funeral of a protester who was killed the day before during a demonstration against insecurity in Kabul.After Trump paved the way for more US forces to be sent to Afghanistan the Taliban, which ruled the war-torn country from 1996-2001, vowed to turn it into a “graveyard” for foreign forces.Afghan authorities welcomed Trump’s decision, while in neighbouring Pakistan officials batted away claims from the US president that Islamabad continued to harbour militant sanctuaries.Earlier this week Pakistan postponed a visit by a US diplomat who had been due to arrive Monday. The delegation led by Assistant Secretary of State for South and Central Asian Alice Wells was set to be the first major visit by an American official since Trump’s comments.Pakistan later announced talks with China’s special envoy on Afghan affairs, where the Chinese official “lauded Pakistan’s contribution and sacrifices made in the fight against terrorism”, according to a statement.IS insurgents have also carried out a number of deadly attacks in Kabul recently.On Friday they claimed a suicide bomb and gun attack on a Shiite mosque that killed 28 worshippers.They also killed two in an attack on the Iraq embassy earlier this month.
A view of the debris inside Notre-Dame de Paris in the aftermath of a fire that devastated the cathedral, during the visit of French Interior Minister Christophe Castaner (not pictured) in Paris, France, on 16 April 2019. Photo: ReutersPrime minister Sheikh Hasina on Tuesday expressed profound shock after a massive fire damaged the historic Notre Dame Cathedral in Paris, reports UNB.”We’re terribly shocked and deeply saddened at the colossal damage to the Cathedral of Notre Dame due to a catastrophic fire on Monday,” she said in a message sent to France president Emmanuel Macron.Sheikh Hasina noted that damage to this iconic Cathedral is most tragic and heart wrenching not only for the people of France but for the entire humanity.”We share the pain and grief of the French people,” she said. “Our thoughts and prayers are with the people of France.”The Cathedral, located on an island in the Seine River, is one of the world’s most visited tourist destinations, drawing some 13 million people each year, according to AP.The world reacted in shock as a massive fire engulfed the Cathedral on Monday.
Google’s security analysis efforts are appreciated and benefit the Android platform, however a company as powerful as Google should practice more responsible disclosure timing than this, and not endanger users in the course of its counter-PR efforts against Epic’s distribution of Fortnite outside of Google Play.”Ultimately, who’s in the right and who’s in the wrong? Honestly, neither company is. Google is right that Epic’s decision to not release Fortnite through the Play Store leaves the app more vulnerable. As my colleague, Mashable tech reporter Matt Binder, previously made clear: Android users need to disable certain Android security permissions in order to install Fortnite and there’s no guarantee they’ll remember to turn them back on after doing so.Maybe Google really is chafing at the idea of not getting any revenue from the massively popular game (apps listed on Google Play pay a share of their sales to Google), as Sweeney implied. But the Android gatekeeper maintains that its speedy disclosure of the exploit was done in the name of user security. Following Sweeney’s statement, Google had only this to say in response to Mashable’s request for comment: “User security is our top priority, and as part of our proactive monitoring for malware we identified a vulnerability in the Fortnite installer. We immediately notified Epic Games and they fixed the issue.”And it’s true, Google does have a responsibility to ensure that users are safe. Otherwise, third-party developers could give the entire platform an even worse reputation.That said, if Google truly cares about protecting its users first and foremost, it should have been more flexible on its bug disclosure deadline so as to not tip off hackers so quickly. That’s why Epic asked for 90 days to begin with.The disagreements between Google and Epic should not be overlooked. Google may wish to have nothing to do with Fortnite after being shunned by Epic Games, but their paths will inevitably cross because of the Android platform.It’s possible Google will discover vulnerabilities in future versions of the Fortnite installerm or even other app installers from other companies that decide to follow in Epic’s footsteps and not offer their apps in the Play Store. Will Google have to monitor and perform security audits on all of those as well in order to protect Android users? Hard to say, but it’s sure gonna be interesting to watch from the sidelines.If anyone’s laughing at this turn of events, it’s Apple. The company’s closed platform means all apps must be released through the App Store. By not allowing apps to be officially released in any other way, Apple has guarded itself against the issue Google’s now facing.With additional reporting by Adam Rosenberg. Epic Games’ decision to release the Android version of its hit game Fortnite without going through Google’s official channels may open its users to malware.Image: EPIC GAMESBy Raymond Wong2018-08-25 18:57:00 UTC An Epic security engineer, at my urging, requested Google delay public disclosure for the typical 90 days to allow time for the update to be more widely installed. Google refused. You can read it all at https://issuetracker.google.com/issues/112630336 Google essentially got slapped in the face when Epic Games, the developer of the super popular Fortnite, decided not to make the game available through the Play Store, but via its own app.Google warned Epic that doing so could potentially put Android users at greater security risk, but the game developer brushed it off, insisting on going it alone for several reasons — including not having to give Google a cut in-app revenue and “embracing open platforms.”Well, now the worst has happened. Despite having no obligation to do so, Google recently discovered an exploit within the Fortnite installer app that allowed malicious apps installed on one’s Android phone to hijack the download process so that instead of downloading the game from Epic’s server, it could download and install something entirely different, which could potentially leave the device open to attacks.Here’s a quick run-down of what happened:Google first discovered the vulnerability inside of the Fortnite installer app on Aug. 15 and immediately notified Epic. Details for the exploit weren’t public yet. Within 48 hours, Epic patched the Fortnite installer and deployed it to all Android users who installed the app. Here’s where things get a little ugly. Even though Epic quickly released a patch for the installer app, it asked Google not to disclose the details of the exploit until after 90 days. Not only would there be more time for users to update their installer apps, but hackers also wouldn’t be able to take advantage of the bug.However, Google’s bug disclosure guidelines explicitly states the following:“This bug is subject to a 90-day disclosure deadline. After 90 days elapse or a patch has been made broadly available, the bug report – including any comments and attachments – will become visible to the public.”Despite Epic’s request for Google to wait the full 90 days before disclosing the exploit, Google abided by its own guidelines and shared the details.Per a Google rep posting to an Issue Tracker thread on the bug report:“…now the patched version of Fortnite Installer has been available for 7 days we will proceed to unrestrict this issue in line with Google’s standard disclosure practices”.Naturally, the Fortnite developer wasn’t happy about Google’s decision at all. Epic provided Mashable the following comment from CEO Tim Sweeney:“Epic genuinely appreciated Google’s effort to perform an in-depth security audit of Fortnite immediately following our release on Android, and share the results with Epic so we could speedily issue an update to fix the flaw they discovered. However, it was irresponsible of Google to publicly disclose the technical details of the flaw so quickly, while many installations had not yet been updated and were still vulnerable.
Example of full-dose, 10 percent low-dose and algorithm-enhanced low-dose. Image courtesy of Enhao Gong, Ph.D. News | Ultrasound Imaging | March 07, 2019 Ultrasound Societies Urge FDA to Remove Black Box Warning on Contrast Agents National and international ultrasound societies are urging the U.S. Food and Drug Administration to remove the “black… read more News | Cardiovascular Ultrasound | August 07, 2019 Contrast Use in First Transthoracic Echocardiogram for Heart Failure Reduces Repeat Testing Heart failure is the fourth most common cause for all admission to U.S. hospitals, and it is the most common reason for… read more News | Neuro Imaging | March 18, 2019 Non-Contrast MRI Effective in Monitoring MS Patients Brain magnetic resonance imaging (MRI) without contrast agent is just as effective as the contrast-enhanced approach… read more Two brain metastases from primary lung cancer are contrast enhanced in the brain of a 61-year-old male. Speakers at AHRA 2019 will state that ProHance and other macrocyclic MR agents present a very low risk to patients. Images courtesy of Bracco Over the past year, headlines across industry and consumer media have highlighted FDA warnings on the dangers of gadolinium-based contrast agents. To date, it has become common knowledge and a FDA black box warning that gadolinium-based agents run the risk of causing Nephrogenic Systemic Fibrosis or Nephrogenic Fibrosing Dermopathy (NSF/NFD). While the dust has yet not settled, the industry has turned its attention to a recent study comparing gadolinium-based contrast agents, now stirring up debate over the significance of reader preference as it relates to diagnostic efficacy. Measuring reader preferenceThe ENHANCE study results show that the use of a gadobenate dimeglumine agent, MultiHance, over another commonly used magnetic resonance imaging (MRI) contrast agent, OMNISCAN, may enhance clinicians’ ability to visualize lesions of the brain. Both of these agents are used for diagnosing several central nervous system disorders – conditions that have in common either a breakdown of the blood brain barrier or some sort of neovascularity or related vessels. Indications would include brain tumors – primary or metastatic – or infections.Results of the ENHANCE Study, which are published online in the American Journal of Neuroradiology, suggest that the higher relaxivity of the gadobenate dimeglumine agent, MultiHance by Bracco Diagnostics Inc., may be linked to greater signal intensity, better contrast enhancement and better lesion conspicuity in MRI of the brain.The study’s aim was to compare the two agents, MultiHance and Omniscan, using a carefully controlled multicenter, double-blind, randomized, intraindividual, crossover study design in which each of the 113 patients received 0.1 mmol/kg doses of both agents in two identical MR imaging examinations. The two contrast injections were performed in a blinded and fully randomized manner with an interval of two to fourteen days between administrations, to avoid any carry over effects. Half of the patients received MultiHance for their first exam and the other half received Omniscan first. Imaging parameters and post-dose acquisition times were kept identical for the two exams in each patient. Images were evaluated by three independent and experienced neuroradiologists, who were unaffiliated with the enrollment centers and fully blinded to any clinical information about the patients and the agents used in the two exams. Image assessments were made in terms of diagnostic information (lesion border delineation, definition of disease extent, visualization of lesion internal morphology, lesion contrast enhancement) and quantitative parameters (percent of enhancement and CNR). After the researchers compared the agents, they concluded (pIt is important to note in the opinion of Richard Vitti, M.D., associate director medical and professional services for GE Healthcare, that the ENHANCE study compares the readers’ preference but not diagnostic superiority of one contrast agent over another.“The ENHANCE study looks at reader preferences, so it is not comparing diagnostic efficacy,” indicated Dr. Vitti. “In other words, it is not showing that patient outcomes are affected, that patient surgical approaches were affected or that patient outcomes were better by having a scan with one agent rather than another.He added, “It’s really a reader preference comparison and there are many things that can affect a reader’s preference. For instance one neuroradiologist may prefer one agent over another because of training or experience.” Sensitivity a sticking pointMultiHance also met the endpoint used in the study for quantitative parameters linked to the contrast enhancement obtained with the two agents (contrast-to-noise ratio, [CNR]). Dr. Vitti is quick to point out that the research acknowledges that all of the studies were diagnostically adequate for interpretation, adding, “An interesting point is that they were able to see the lesions with both tracers. So that is why they are able to put a cursor over both of them and make the measurements.”According to one of the study’s principal investigators, Howard Rowley, M.D., of the University of Wisconsin in Madison, the key differential between MultiHance and other gadolinium contrast agents may be that it demonstrates weak and transient interactions with serum proteins, which result in a proton magnetic relaxivity that is approximately twice that of other gadolinium contrast agents available for sale in the U.S. for CNS imaging. Researchers suggest that the higher relaxivity may result in greater signal intensity enhancement and better contrast enhancement at equivalent dose for CNS imaging.Dr. Rowley said the study produced “significant findings relative to the performance of one of the most widely used gadolinium agents administered in MRI procedures to improve the conspicuity and detectability of central nervous system (CNS) lesions.” He added, “These results are consistent in showing some clear advantages relative to performance associated with using the higher relaxivity agent versus another well-known widely used gadolinium agent in MR imaging of the brain.”However, greater lesion enhancement does not necessarily indicate diagnostic superiority. “When they make the measurements, the lesions do appear brighter by the measurements they make. But that doesn’t mean the study is more diagnostic because obviously they are seeing the lesions with both agents. They say in the discussion that all of the studies were diagnostically adequate for interpretation,” said Dr. Vitti. “I know they have published a great deal about this measurable difference and R1 relaxivity. But this has not been born out in clinical use of this product in the last couple of years as impacting patient care or diagnostic efficacy as far as anyone can tell.” The benefit of detecting just one more tumor, according to Dr. Rowley, is it can alter the entire direction of treatment. “The metrics we look at are the things we in clinical medicine look at everyday to help determine treatment programs, whether it’s surgical or radiation,” Dr. Rowley explained. “Finding one or more additional lesion could alter the decision to proceed with certain therapies or certainly in the case of radiation or surgery, it could help target additional lesions or could heed more complete detection of lesions.” Although better tumor detection could mean a significantly more effective treatment, the study does not set out to demonstrate improved diagnostic efficacy.Alzheimer’s indication?Contrast has implications for a wide variety of situations beyond infection and tumors, such as multiple sclerosis, which also can show enhancement in the acute phase. One of the promises of agents like MultiHance is the potential to detect Alzheimer’s disease.“In the area of dementia, usually the contrast is given more to exclude another pathology. For example, a pyramidal lobe tumors exam might end up as dementia, but the MRI would be done in part to exclude structural causes of dementia,” noted Dr. Rowley. “With Alzheimer’s, right now contrast agents like PIB (Pittsburgh Compound-B) provide a more direct way to view that pathology.“We know that MultiHance not only has an R1 effect, which is the traditional relaxation behavior which translates through the contrast enhancement on T1 images. We know that it also has a greater affect on R2 used for looking at brain perfusion when we inject a bolus of contrast. And there are a lot of groups looking at the ability of MRI perfusion studies to start to sort out different types of dementia, whether vascular-related dementia or more traditional degenerative conditions like Alzheimer’s or other subtypes,” said Dr. Rowley. “It is a little early to say this is ready for clinical work, but an added advantage is that it gives you a greater R2 effect, and therefore it facilitates perfusion exams, which are finding wider application in stroke, dementia and other diseases.”He added, “There are recent studies that look at stroke triage, using a combination of diffusion-related images with ischemic injury and perfusion-weighted images that show areas at risk called ischemic penumbra. Having an agent that gives you excellent perfusion capabilities is also a benefit. By extension, we would expect to benefit from that as well.”And by extension, studies like ENHANCE may hold important clues that lead researchers to discover the right agent to detect stroke, Alzheimer’s or other neurological diseases. Connection with the contrast crisisThe safety profile for gadolinium-based contrast agents has been under tremendous scrutiny by the FDA ever since 25 cases of NSF/NFD were reported in patients with kidney failure who received a leading gadolinium-containing contrast agent and took a magnetic resonance angiography (MRA) test. The FDA pointed to instances when gadolinium-based contrast was used for MRA exams, pointing out that the amount of dose given to patients undergoing an MRA test is often higher (up to three times) than the approved dose for MRI. The agency has asked manufacturers to include a new boxed warning on the product labeling of all gadolinium-based contrast agents, which are used to enhance the quality of MRI.“All of the gadolinium-based contrast agents in the U.S. carry the same warning about the risk of NSF. So the FDA concluded that the risk of NSF in renally impaired patients is a risk for all the agents currently on the market,” indicated Dr. Vitti. “If you are able to identify patients at risk and to follow the FDA guidelines and only use gadolinium-based contrast agents when there is a good reason to in those patients, then in the majority of situations you will avoid causing NSF. If patients are dosed according to the package labels, most of the time you will avoid NSF.”Although researchers in the ENHANCE study did not look directly at NSF, they did look at adverse affects and in the short term of the trial, they identified adverse affect differences between gadodiamide and gadobenate dimeglumine. “In other work, including work we have done at the University of Wisconsin, we have seen differences among the agents, and as the readers are aware, some of the agents seem to be disproportionately represented in cases of NSF. So it’s not a direct affect of our study, but I think it is interesting to note that MultiHance, which we did find to be beneficial for medical enhancement reasons and interpretation of MRI, has also been an agent that seems to have a very favorable safety profile with respect to NSF,” said Dr. Rowley.Dr. Rowley suggests a strategy for reducing dose while still acquiring enhanced images to diminish the risk of patients developing NSF. “We didn’t study this directly, all of these studies were done with the FDA-recommended, gold dose for MultiHance, but if you look at the quantity of enhancement, you find that in general MultiHance produces roughly double the enhancement of a traditional agent. In other words, giving a single dose of MultiHance and Omniscan, you see twice as much enhancement as if you gave a double dose on Omniscan and a single dose of MultiHance. Once again, Dr. Vitti disputes this claim. “I don’t think you can make that conclusion. If that is what they were trying to show, they should have compared 0.1 millimul of MultiHance to 0.2 millimul of Omniscan, if they were trying to prove that. People have calculated based on the R1 measurements from these agents, it’s probably not double, it’s probably more like a third, if you do the calculations from the physics standpoint.”Even with a slight enhancement, Dr. Rowley suggests that MultiHance allows you to reduce the dose and still getting similar lesion enhancement to a full dose of a non-protein binding, traditional agent.“When we are trying to be careful particularly with someone who might have risk factors, or other reasons to conserve the contrast agent, it’s our intention based on this knowledge, that you could use a half dose of MultiHance and expect to get similar enhancement to a full dose of a non-protein binding, traditional agent. That is by inference,” said Dr. Rowley. FacebookTwitterLinkedInPrint分享 Feature | Contrast Media Injectors | April 11, 2019 | By Jeff Zagoudis Using Artificial Intelligence to Reduce Gadolinium Contrast One of the most controversial issues in radiology in recent years has been the use of… read more Feature | October 02, 2008 | Cristen C. Bolan Agents Compete on Preference and Performance Drs. debate reader preference and diagnostic efficacy. Technology | Contrast Media | July 15, 2019 FDA Approves Bayer’s Gadavist Contrast for Cardiac MRI in Adult Coronary Artery Disease Patients The U.S. Food and Drug Administration (FDA) has approved Gadavist injection for use in cardiac magnetic resonance… read more Technology | Contrast Media | August 05, 2019 Bracco Receives FDA Approval for Varibar Thin Liquid for Oral Suspension Bracco Diagnostics Inc. announced U.S. Food and Drug Administration (FDA) approval for Varibar Thin Liquid (barium… read more Related Content GU12171120 MultiHance and OMNISCAN are commonly used magnetic resonance imaging (MRI) contrast agents. Photo courtesy of Bracco. Feature | Contrast Media | July 18, 2019 | By Greg Freiherr How To Manage Risk in the MR Suite Macrocyclic contrast agents have the best safety profile of all the magnetic resonance (MR) contrast media that are n read more News | Radiology Business | April 24, 2019 ITN Wins Jesse H. Neal Award for Best Technical Content April 24, 2019 — Imaging Technology News (ITN) was recently named the 2019 Jesse H. read more Sponsored Content | Case Study | Contrast Media Injectors | April 02, 2019 The Power In Prefilled Syringes The continuing search for advantages to improve workflow has radiology departments constantly searching for new solut read more Sponsored Content | Case Study | Contrast Media | January 30, 2019 Captisol-enabled Contrast Media with Reduced Renal Toxicity in Development The medical imaging market relies heavily on contrast media, injected into patients to increase the contrast of bodil read more